Acute kidney injury is a known clinical risk factor for delirium, an acute cognitive dysfunction that is commonly encountered in the critically ill population. In this comprehensive review of clinical and basic research studies, we detail the epidemiology, clinical implications, pathogenesis, and management strategies of patients with acute kidney injury-associated delirium. Specifically
Acute kidney injury (AKI) is a sudden loss of renal function with a subsequent rise in creatinine and blood urea nitrogen ( BUN ). It is most frequently caused by decreased renal perfusion ( prerenal) but may also be due to direct damage to the kidneys (intrarenal or intrinsic) or inadequate urine drainage (postrenal).
the majority were medical patients (80%, e.g. sepsis) Fragility index = “-18” the outcome is consistent with the pre-existing literature (see systematic review by Wierstra et al, 2016) ELAIN trial (Zarbock et al, 2016) single-center RCT from Germany; n = 231 critically ill adults with stage 2 AKI; Intervention: immediate RRT (early RRT)
AKI is a sudden episode of kidney damage or kidney failure that can cause harmful toxins and fluid to build up in your body. Learn about the causes, symptoms, diagnosis and treatment of AKI, and how it differs from chronic kidney disease (CKD).
In all cases of acute kidney injury (AKI), creatinine and urea build up in the blood over several days, and fluid and electrolyte disorders develop. The most serious of these disorders are hyperkalemia Hyperkalemia Hyperkalemia is a serum potassium concentration > 5.5 mEq/L (> 5.5 mmol/L), usually resulting from decreased renal potassium excretion or abnormal movement of potassium out of cells.
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